Slide 1

Hydrogen Ion Balance

The task of the kidney in acid-base balance is
excretion of the daily acid load

Buffers

Buffering of an acid load

The Henderson Hasselbalch Equation

Filtered Bicarbonate

HCO₃ Reabsorption by H⁺ secretion

HCO₃ reabsorption / H⁺ secretion occurs in the
            Proximal and Collecting tubules

H⁺ Secretion in the Proximal Tubule

Proximal Tubule

Slide 12

The Membrane Potential Generated
by Na Absorption Regulates
H⁺ and K⁺   Secretion in Collecting Tubules

Regulation of H⁺ Secretion in the Collecting Tubule
by Aldosterone

^{Aldosterone Action in Collecting Duct}

CO₂ stimulates Exocytosis
    of H⁺ATPase Vesicles

pH of Tubular Urine

Collecting Tubule Urine pH

H⁺ Secretion in the Collecting Tubule

Gluconeogenesis

Acid Ingestion increases Ammonia Synthesis and Excretion

Regulation of H⁺ Transport

Slide 23

Potassium Distribution

Plasma Potassium Concentration

Insulin Increases K⁺ Uptake by Cells

Renal Potassium Handling

K  Secretion in Collecting Duct

Driving Forces for K  Secretion
in Collecting Duct

K⁺ Urinary Excretion and Urine Flow Rate

Interaction Between Aldosterone and Urine Flow in K⁺ Excretion

Regulation of K Secretion