| SYNTHESIS
AND “SECRETION” OF STEROID HORMONES BY ADRENAL CORTEX |
| 1 |
|
|
|
|
|
|
|
| CHOLESTEROL
IS TAKEN UP INTO MITOCHONDRIA |
||||||
| EITHER
DIRECTLY FROM PLASMA LDL/HDL OR
FROM |
||||||
| INTRACELLULAR
CHOLESTEROL ESTERS “STORED” |
||||||
| IN LIPID
DROPLETS |
||||||
|
|
|
|
|
| StAR
facilitates transfer of |
||||
| cholesterol
molecules between |
||||
| inner
and outer membranes |
||||
| ALDOSTERONE |
| 2 |
|
|
|
|
| Cholesterol
in |
|||
| Intracellular |
|||
| Lipid
droplets |
|||
|
|
|
| DIFFUSION
OF STEROIDS |
||
| OUT OF CELL |
||
| CORTISOL |
| 4 |
| P450c11 |
| 11-HYDROXYLASE |
|
|
|
| ANDROGEN |
||
| PRECURSORS |
||
|
|
|
| REMOVAL
OF |
||
| SIDE CHAIN |
||
| 17-OH
PROGESTERONE |
|
|
|
|
|
| ENDOPLASMIC
RETICULUM |
||||
| OXIDATION
OF STEROID NUCLEUS |
||||
| BY SPECIFIC P-450 HYDROXYLASES |
||||
| GONADS |
| 3 |