“PRE-RECEPTOR REGULATION” OF STEROID HORMONE ACTION
	11ß-HYDROXYSTEROID DEHYDROGENASE - (11ß-HSD)
				11ß- HSD TYPE 1 (LIVER)																																																					11ß- HSD TYPE 2 (KIDNEY)
			CORTISOL
																		ACTIVE																																								CORTISONE																	INACTIVE
																																																																																																	OH
																																														CH20H
																																																																C				O
																																														C				O
																																																																																					12
																																																																																												18
																																12
																																							18																																																															OH
																					OH
																																																OH
																																																																																																									16
																																																																11
																																																																															13
																																																				16
																												11
																																									13
																																																																																				C
																																																																															40
																																																																1
																																																																					19
											1
																	19
																																																																																																						15
																																																																																							14
																																																	15																												9
																																								14
																																																													2
																										9
							2
																																																																																									8
																																																																						10
																																			8
															10
																																																																												B
																									B
																																																																3
																																																																																								7
									3
																																		7
																																																																								5
																			5																																								O
					O																																																																									6
																																																																			4
												4															6