| STRUCTURE
& FUNCTION OF MAJOR HORMONES |
| CHEMICAL
STRUCTURE |
| MAJOR
FUNCTION |
| HORMONE |
| M.W. |
| TRIIODOTHYRONINE
(T3) |
| <1000 |
|
|
|
| GROWTH,
METABOLISM & |
||
| DEVELOPMENT |
||
| IODINATED
TYROSINE DERIVATIVES |
| THYROXINE
(T4) |
| <1000 |
| '' |
| STEROIDS |
| CHOLESTEROL
DERIVATIVES |
| <1000 |
| ANTI-DIURETIC
HORMONE |
| ARG-VASOPRESSIN
(ADH) |
| ~1000 |
| (S-S)
LINKED CYCLIC NONAPEPTIDES |
| OXYTOCIN |
| SUCKLING
RESPONSE |
| ~1000 |
| GLUCAGON |
| ~3,500 |
| 29-RESIDUE PEPTIDE |
| PLASMA
GLUCOSE |
| CALCITONIN |
| ~ |
| 32-RESIDUE PEPTIDE |
| PLASMA
Ca |
|
|
|
| STIMULATES RELEASE |
||
| OF
CORTICAL STEROIDS |
||
|
|
| 39-RESIDUE
PEPTIDE DERIVED |
|
| FROM 31K POMC PRECURSOR |
|
| ADRENOCORICOTROPHIC |
| 4,500 |
| HORMONE
(ACTH) |
|
|
|
| 51-RESIDUE
PEPTIDE WITH |
||
| (S-S)-LINKED
A AND B CHAINS |
||
| PLASMA
GLUCOSE |
| 6,000 |
| INSULIN |
| LIPOLYSIS |
| PARATHYROID
HORMONE |
| PLASMA
CALCIUM |
| 84-RESIDUE
PEPTIDE |
| 9,500 |
| PROLACTIN
(PRL) |
|
|
|
| 198
/191 RESIDUE GLYCOPROTEINS WITH |
||
| ~ 80%
HOMOLOGY |
||
| LACTOGENESIS |
| 23,000 |
| GROWTH
HORMONE (GH) |
| GROWTH
/ METABOLISM |
| 22,000 |
|
|
| THYROID-STIMULATING |
|
| HORMONE (TSH) |
|
|
|
|
| STIMULATES
RELEASE |
||
| OF T3 AND T4 |
||
| 28,000 |
|
|
|
|
|
| GLYCOPROTEINS
WITH: |
||||
| COMMON
ALPHA SUBUNIT |
||||
| AND
VARIABLE BETA SUBUNIT |
||||
| 30,000 |
|
|
|
| FOLLICLE-STIMULATING |
||
| HORMONE (FSH) |
||
| 30,000 |
|
|
| CHORIONIC |
|
| GONADOTROPHIN
(hCG) |
|
|
|
| MAINTENANCE
OF |
|
| CORPUS LUTEUM |
|
| 57,000 |
| LEPTIN: 16kDa 139-RESIDUE PEPTIDE |
