| TESTOSTERONE (AR) |
| GLUCOCORTICOIDS (GR) |
| PROGESTERONE
(PR) |
| 1 |
| STEROID
HORMONES DIFFUSE ACROSS PLASMA MEMBRANE |
|
|
|
| STEROID
HORMONES BIND TO SPECIFIC, SOLUBLE |
||
| INTRACELLULAR
RECEPTORS |
||
| 2 |
|
|
|
|
|
|
|
|
|
| GLUCOCORTICOSTEROID |
||||||||
| HORMONES
BIND TO A |
||||||||
| SOLUBLE
INTRACELLULAR |
||||||||
| GR
RECEPTOR: hsp90 |
||||||||
| COMPLEX |
||||||||
| NUCLEUS |
| + |
| 3 |
| - ve HRE |
| +ve HRE |
| - |
|
|
|
|
|
|
| STEROID
RECEPTORS TRANSLOCATE |
|||||
| INTO
THE NUCLEUS AND INTERACT WITH |
|||||
| GRE’S,
OTHER HRE’s AND COACTIVATOR |
|||||
| MOLECULES |
|||||
|
|
|
|
| GRE:
GLUCOCORTICOID |
|||
| RESPONSE ELEMENT |
|||
| HRE:
HORMONE RESPONSE |
|||
| ELEMENT |
|||