| STIMULUS
INDUCED DIMERIZATION |
| G-PROTEIN
COUPLED |
| EGF/PDGF |
| TSH BINDING
SITE |
| PDGF |
| PDGF |
|
|
|
| CELL |
||
| MEMBRANE |
||
|
|
|
| CELL |
||
| MEMBRANE |
||
|
|
|
|
|
|
|
| SMALL
LIGAND |
||||||
| BINDING SITE |
||||||
| ACCOMODATES |
||||||
| CATECHOLAMINES |
||||||
| G-PROTEIN |
| P |
| P |
| P |
| P |
|
|
|
| Autophosphorylation |
||
| by
intrinsic tyrosine kinase |
||
|
|
|
| DESENSITIZATION
BY |
||
| b-ark or pkc |
||