|
|
|
| GROWTH
FACTOR |
||
| RECPTOR |
||
|
|
|
| SIGNAL
TRANSDUCTION FROM CELL |
||
| SURFACE
RECEPTORS TO THE NUCLEUS |
||
|
|
|
|
|
| TYROSINE
PHOSPHORYLATION OF |
||||
| RECEPTOR
RECRUITS Grb2-Sos TO |
||||
| PLASMA
MEMBRANE |
||||
|
|
|
| PROTEIN |
||
| KINASE
C |
||
|
|
|
| ACTIVATION
OF Ras BY GUANINE |
||
| NUCLEOTIDE EXCHANGE FACTOR |
||
| GTP |
| GDP |
| Ras |
|
|
|
| Raf/MAPKKK
ACTIVATED |
||
| BY
RAS OR PROTEIN KINASE C |
||
| ATP |
| MAPKKK |
| ADP |
| MAPKK |
|
|
|
|
|
| ACTIVATION
OF MAP- KINASE |
||||
| REQUIRES
BOTH THREONINE AND |
||||
| TYROSINE
PHOSPHORYLATION |
||||
| ATP |
| MAPK |
| ADP |
| NUCLEUS |
|
|
|
| PHOSPHORYLATION
OF TRANSCRIPTION |
||
| FACTORS IN NUCLEUS |
||