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| ARRANGEMENT
OF BINDING DOMAINS |
||
| AND CATALYTIC SITES |
||
| PROTEIN |
| src
kinase |
| --Myr----SH3----SH3----SH2----Tyr kinase--- |
| Btk |
| --PH----Pro----SH3----SH2----Tyr kinase---- |
| Shc |
| --PTB----SH2- (‘Collagen-like’) |
| Grb-2 |
| --SH3----SH2----SH3 |
| Shp-2 (Syp) |
| --SH2----SH2----PTPase |
| PLCa |
| ? |
| --PH----PLC----PLC-- |
| PLCb |
| PLCg |
| --PH----PLC----SH2----SH2----SH3----PLC |
| PLCd |
| --PH----PLC----PLC |
| PKB |
| --PH---- Ser/Thr kinase |
| p120Ras-GAP |
| --SH2----SH3----SH2----PH----GAP |