| K+ |
|
|
|
|
|
|
|
| THESE
CHANNELS ARE ALSO |
||||||
| SENSITIVE
TO OTHER STIMULI |
||||||
| SUCH
AS ACETYLCHOLINE AND |
||||||
| CATECHOLAMINES |
||||||
|
|
|
|
|
| REGULATION
OF |
||||
| INSULIN SECRETION |
||||
| BY GLUCOSE |
||||
| Ca2+ |
| - |
| K+ |
| Ca2+ |
| ATP/ADP |
|
|
|
|
|
| GLUCOSE |
||||
| OXIDATION |
||||
| GLYCOLYSIS |
||||
| Ca2+ |
|
|
|
| INSULIN |
||
| SECRETION |
||
| GLUCOSE |
| ATP |
|
|
|
| GLUT2 |
||
| KM >15mM |
||
|
|
|
| UNLIKE
HEXOKINASE, GLUCOKINASE |
||
| IS NOT
INHIBITED BY GLUCOSE-6-P |
||
| GLUCOSE |