No Slide Title


_{INTRACELLULAR RECEPTORS:“LIGAND-ACTIVATED}

	_{TRANSCRIPTION FACTORS”}


_{HORMONES WITH INTRACELLULAR RECEPTORS ARE HYDROPHOBIC ALLOWING DIFFUSION}
	_{ACROSS PLASMA MEMBRANE}


	_{HIGHLY VARIABLE}

_{TRANSCRIPTION-ACTIVATION}

		_DOMAIN


_{HIGHLY CONSERVED (66 AMINO ACID)}

	_{DNA-BINDING DOMAIN CONTAINING}

		_{TWO “ZINC FINGERS”}

_N

_C


	_{THIS PROBLEM IS SOLVED BY UTILISING THE}
_{ENERGY OF HORMONE BINDING AT THE CELL}
		_{SURFACE TO ALTER CONFORMATION OF}
		_{TRANSMEMBRANE PROTEINS AND THEIR}
			_{INTERACTIONS WITH INTRACELLULAR}
				_PROTEINS


		_{POLYPEPTIDE HORMONES ARE}
_{HYDROPHILIC AND CANNOT DIFFUSE}
	_{ACROSS THE PLASMA MEMBRANE}