| HORMONES
HAVE VARIABLE IN VIVO “STABILITY” |
|
|
|
| POTENTIAL
REASONS |
||
| FOR
VARIABLE STABILITY |
||
| t˝ |
| HORMONE |
|
|
|
|
|
| STEROIDS
ARE HYDROPHOBIC |
||||
| AND MAY
PARTITION INTO |
||||
| MEMBRANES AND ADIPOSE TISSUE |
||||
| 3h |
| FSH |
| 70 min |
| CORTISOL |
|
|
|
| HORMONE
CLEAVED BY SPECIFIC |
||
| PEPTIDASES
IN PLASMA |
||
| ALDOSTERONE |
| 70 min |
| LH |
| 60 min |
|
|
|
|
|
| HORMONE
FORMS COMPLEX WITH |
||||
| BINDING
PROTEIN WHICH PROTECTS |
||||
| IT FROM
DEGRADATION |
||||
| I5 min |
| ACTH |
| ADH |
| 8 min |
|
|
|
|
|
|
|
|
|
| SHORT
PEPTIDES ARE PARTICULARLY |
||||||||
| VULNERABLE TO DEGRADATION |
||||||||
| BECAUSE THERE ARE |
||||||||
| FEW
CONSTRAINTS ON THEIR |
||||||||
| CONFORMATION |
||||||||
| 5-8 min |
| INSULIN |
| 3-5 min |
| OXYTOCIN |