PowerPoint Presentation

GLUCOCORTICOIDS (GR)

OTHER STEROID HORMONES

PROGESTERONE (PR)

TESTOSTERONE (AR)

ESTROGEN (ER)

STEROID HORMONES DIFFUSE ACROSS PLASMA MEMBRANE

STEROID HORMONES BIND TO SPECIFIC, SOLUBLE INTRACELLULAR RECEPTORS

release of inhibitory

hsp90 proteins reveals

nuclear localization signal on

GR receptor

STEROID RECEPTORS TRANSLOCATE INTO THE NUCLEUS AND INTERACT WITH GRE�S, OTHER HRE�s AND COACTIVATOR MOLECULES

+ve HRE

NUCLEUS

- ve HRE

GLUCOCORTICOSTEROID

HORMONES BIND TO A SOLUBLE INTRACELLULAR

GR RECEPTOR: hsp90 COMPLEX

STEROID-RESPONSIVE

TARGET GENES

GRE: GLUCOCORTICOID

RESPONSE ELEMENT

HRE: HORMONE RESPONSE ELEMENT


	_{LOCATION OF RECEPT0R IS VARIABLE}
	_{ADD DRAWING OFNUCLEAR HORMONE RECEPTOR}
	_{3 MAJOR DOMAINS}
	_{VARIABLE n-TERMINUS}
	_{�ZINC FINGERS� BIND DNA}

	_{GR AND AR MAINLY CYTOPLASMIIC}
	_{PR AND ER MAINLY NUCLEAR}
	_{HIGHLY CONSERVED DNA BINDING REGION (66 RESIDUES)}

	_{STEROID AND/ OR THYROID HORMONE EACH EFFECTS APPROX 1% OF GENES IN SOME CELLS}
	_TAMOXIFEN