REGULATION OF TRANSCRIPTION BY NON-STEROIDAL HORMONES
HORMONE-RESPONSIVE TARGET GENES
HRE
NUCLEUS
HORMONE BINDING
RELIEVES REPRESSION
BY RETINOID X RECEPTOR
TRANSCRIPTION
HORMONE-RESPONSIVE TARGET GENES
+
VITAMIN D
RETINOIC ACID
THYROID HORMONE
RETINOID X RECEPTOR SUBUNIT (RX)
REPRESSES TRANSCRIPTIONAL
ACTIVATION BY HORMONE RECEPTOR (R)
R
HRE
RX
-
NUCLEUS
PLUS HORMONES
NO HORMONES
HORMONE-RESPONSIVE TARGET GENES
NO TRANSCRIPTION
N
C