| REM Sleep |
| STRESS |
| + |
|
|
|
| REGULATION
OF ADRENAL |
||
| HORMONE
SECRETION |
||
| + |
| - |
| - |
| HYPOTHALAMUS |
| CORTISOL |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| “ADDISON’S DISEASE” |
|||||||||||||
| DESTRUCTION
OF THE |
|||||||||||||
| ADRENAL
GLAND BY DISEASE |
|||||||||||||
| OR
BY SURGICAL REMOVAL OF |
|||||||||||||
| THE
GLAND. THIS DISEASE IS |
|||||||||||||
| LETHAL
IF NOT TREATED BY |
|||||||||||||
| HORMONE
REPLACEMENT |
|||||||||||||
| THERAPY |
|||||||||||||
| + |
| CRH |
| - |
| PITUITARY |
| TRANSPORT
IN BLOOD |
|
|
|
| BOUND
STEROIDS (90%) |
||
| FREE
STEROIDS (10%) |
||
| ACTH |
| CORTISOL IS
NOT STORED |
| + |
|
|
|
| ADRENAL
CORTEX |
||
| “ZONA
FASCICULATA” |
||
| CHOLESTEROL * |
| STEROIDS |
|
|
|
|
|
| ACTH
STIMULATES STEROID SYNTHESIS WITHIN |
||||
| MINUTES
DUE TO CHOLESTEROL ALREADY PRESENT |
||||
| IN
MITOCHONDRIAL INNER MEMBRANE |
||||
|
|
|
| ANDROGEN |
||
| PRECURSORS |
||