|
|
|
| REGULATION
OF GROWTH |
||
| HORMONE
SECRETION |
||
| Arginine |
|
|
|
|
| exercise |
|||
| STRESS |
|||
| preREM
Sleep |
|||
| + |
| + |
| - |
|
|
|
|
|
|
|
|
| THERE
ARE 6 DISTINCT |
|||||||
| IGF
BINDING PROTEINS |
|||||||
| IGFBP(1-6)
. ONE OF THEM IS |
|||||||
| THE EXTRACELLULAR PORTION |
|||||||
| OF THE GH
RECEPTOR |
|||||||
| + |
| - |
| HYPOTHALAMUS |
| - |
| - |
| + |
| TRANSPORT
IN BLOOD |
| SOMATOSTATIN
/ GHIH |
| GHRH |
| - |
| “SOMATOMEDIN” |
| PITUITARY |
| FREE
IGF’s BOUND IGF’s |
| GROWTH
HORMONE |
|
|
|
|
|
| BASAL
GH ~ 10-10M |
||||
| TOO
LOW TO MEASURE |
||||
| ACCURATELY |
||||
| “SOMATOMEDIN” |
|
|
|
| GROWTH
HORMONE |
||
| IS
SPECIES-SPECIFIC |
||
|
|
|
|
|
| BONE AND CARTILAGE |
||||
| SKELETAL |
||||
| GROWTH
EFFECTS |
||||
|
|
|
| LIVER
AND FIBROBLASTS |
||
| IGF-1
AND IGF-2 SECRETION |
||
|
|
|
|
|
|
|
|
|
| MANY
TISSUES |
||||||||
| METABOLIC
EFFECTS: |
||||||||
| INCREASED LIPOLYSIS |
||||||||
| AND
PROTEIN SYNTHESIS |
||||||||
| DECREASED GLUCOSE USE |
||||||||
