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The
observation that calcitonin (CT) at supraphysiological doses is hypocalcemic, led to the
mistaken
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conclusion
that it was important for calcium homeostasis and this idea has persisted
to this day.
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Despite
these findings there is no readily apparent pathology due to CT excess or deficiency and
there
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is
no evidence that circulating CT is of substantial benefit to
any mammal. ……….. .
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Mammalian
CT at physiological doses is not essential and very likely the CT gene has
survived
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because
of the gene’s alternate mRNA pathway to produce calcitonin-gene-related
peptide found in
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neural
tissues.
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HIRSCH,PF and BARUCH H, ENDOCRINE
2003, 201-208
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