INSULIN RECEPTOR SIGNALING PATHWAY
IRS-1
INHIBITION OF LIPOLYSIS
PY
PY
SH2
PI 3-KINASE
INSULIN
GLUT4
TRANSLOCATION
PI 3-KINASE
INHIBITORS
e.g. WORTMANNIN
BLOCK GLUCOSE
UPTAKE
GSK3
FATTY ACID
SYNTHESIS
GLYCOGEN
SYNTHESIS
GENE
EXPRESSIO
N
PDK