BLOOD FLOWS RADIALLY FROM
CENTER OF ISLET TO THE PERIPHERY FACILITATING
PARACRINE INHIBITION OF GLUCAGON
SECRETION BY INSULIN
VENOUS
BLOOD
ISLETS OF LANGERHANS
MANTLE FORMED BY a CELLS
SECRETING GLUCAGON
(20-25%)
CORE FORMED BY BETA CELLS SECRETING INSULIN
(60-70 % OF TOTAL)
1 MILLION ISLETS EACH
CONTAINING ~2500
CELLS
ARTERIAL BLOOD
VENOUS BLOOD
b CELL
b CELL