REGULATION OF ADRENAL
HORMONE SECRETION
PITUITARY
HYPOTHALAMUS


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TRANSPORT IN BLOOD
ADRENAL CORTEX
�ZONA FASCICULATA�
STRESS
PGLUCOSE


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CRH
ACTH
BOUND STEROIDS (90%)
FREE STEROIDS (10%)
REM Sleep
CHOLESTEROL *
STEROIDS
�ADDISON�S DISEASE� DESTRUCTION OF THE ADRENAL GLAND BY DISEASE OR BY SURGICAL REMOVAL OF THE GLAND.  THIS DISEASE IS LETHAL IF NOT TREATED BY
HORMONE REPLACEMENT THERAPY
ALDOSTERONE
ANDROGEN
PRECURSORS
CORTISOL
ACTH STIMULATES STEROID SYNTHESIS WITHIN MINUTES DUE TO CHOLESTEROL ALREADY PRESENT IN MITOCHONDRIAL INNER MEMBRANE
CORTISOL IS NOT STORED