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TYROSINE

IODINATION

TYROSINE

MONOIODOTYROSINE (MIT)

DIIODOTYROSINE (DIT)

NH2

TYROSINE

IODINATION

SYNTHESIS OF THYROID HORMONES: STEP 1 - IODINATION

Approximately 10% of the tyrosine residues on the 550 amino acid residue Thyroglobulin molecule may become iodinated by the enzyme - thyroid peroxidase acting on the colloid at the luminal surface of the thyroid follicle. These reactions only occur in the thyroid at specific residues in �Hormonogenic� sites located at the extreme ends of the Thyroglobulin molecule.

Tyr

THYROGLOBULIN


	Approximately 10% of the tyrosine residues on the 550 amino acid residue
	Thyroglobulin molecule may become iodinated by the enzyme - thyroid
	peroxidase acting on the colloid at the luminal surface of thyroid follicle.
	These reactions only occur in the thyroid at specific residues in �hormonogenic�
	sites located at the extreme ends of the Thyroglobulin molecule.