PowerPoint Presentation - Low Lectures

Thyroglobulin

CH2CHCOOH

Thyroglobulin

I

I

Tyr

3,5,3�5�-tetraiodothyronine

SYNTHESIS OF THYROID HORMONES: STEP- 2 COUPLING OF IODOTYROSINES

CH2CHCOOH

NH2

+

HO

I

I

I

Tyr

NH2

T

4

Thyroglobulin

I

I

Tyr

CH2CHCOOH

NH2

CH2CHCOOH

I

Tyr

NH2

Thyroglobulin

Tyr

I

I

I

Tyr

O

+

I

T

3

3,5,3�-Triiodothyronine

Coupling of iodotyrosine moities results in the loss

of the peptide linkage to thyroglobulin allowing thyroid

hormones to diffuse across the cell membrane

I

I

Tyr

I

I

I

Tyr

O

I

3

3�

5

5�

HO

HO

HO

HO

HO