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| Cure
of Children with X- |
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| SCID |
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| l | Most
successful human trial to date |
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| l | T
cells lack C cytokine receptor required for lymphoid |
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| proliferation |
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| l | Retroviral
transfer of C cytokine receptor gene into CD34+ |
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| cells |
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| l | Autotransplantation |
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| l | Selection
of corrected cells |
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| l | Normal
immune function in 7/9 patients |
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| l | T
cell leukemia (clonal) in 2/9 patients 3 years post- |
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| transduction |
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