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| Leukemia in
Children with X- |
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| SCID |
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| l | Similar
insertional mutagenesis events in both |
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| children |
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| l | Unregulated
C cytokine receptor gene inserted |
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| into
LMO2 locus |
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| l | Activation
of LMO2, a proliferative gene |
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| l | A
rare event in an early T cell/HSC that leads to a |
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| leukemic
transformation |
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| l | Slow
growth and eventual proliferation of the |
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| clone |
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| l | May
be prevented by regulated C cytokine |
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| receptor
gene |
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