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 |
 |
 |
 |
| l |
Herpes
simplex thymidine kinase
|
|
|
(HSVTK)gene:
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|
|
l |
Specifically
phosphorylates gancyclovir
|
|
and
converts it to a toxic product
|
|
|
|
l |
End
result is tumor cell killing
|
|
|
|
l |
Injected
into brain tumors post-
|
|
|
operatively
|
|
|
|
l |
Patients
treated with gancyclovir
|
|
|
|
l |
Results
equivocal
|
|