Absorption, Distribution, Metabolism and Elimination:
Part I

	Joseph Graziano, Ph.D.

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Major Routes of Drug Administration

	Route of Administration
	Intramuscular:
	Intravenous:
	Absorption Pattern
	Prompt from aqueous solutions, but slow and sustained from repository forms
	Immediate effects,
	since  absorption is
	circumvented

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Major Routes of Drug Administration

	Route of Administration
	Oral Ingestion:
	Subcutaneous:
	Absorption Pattern
	Variable; depends on many factors
	Prompt from aqueous solutions, but slow and sustained from repository forms

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Other Routes of Administration

	Transdermal patch
	Inhalation
	Intra-arterial
	Intrathecal
	Topical:  ocular, dermal, intranasal, intravaginal routes all lead to some systemic absorption

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