Absorption, Distribution, Metabolism and Elimination: 
Part II

Aspirin Metabolism

Organs Involved in Drug Biotransformation

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1.Oxidation
a. Aromatic hydroxylation

b. Aliphatic hydroxylation

d. Oxidative O-dealkylation

e. S-oxidation

4. Conjugation
a. Glycine

b. Glucuronic acid

d. Acetylation

Examples of Characteristic Inducers of the Major P450 Gene Families

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Examples of Inhibitors of the Major P450 Gene Families

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Erythromycin (an antibiotic) and Verapamil ( a calcium channel blocker) are also important inhibitors of P-450

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