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Anxiety Disorders

Pharmacotherapy

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Genetic and Environmental Factors in Anxiety Disorders

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"Behavioral validation"

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Anatomy of the serotonergic system

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Construction of 5-HT1AR KO mice

5-HT1A KNOCKOUT

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Does forebrain receptor reverse the phenotype of the 5-HT1A KO mice?

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Receptor OFF in adulthood

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Receptor ON at P21

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Forebrain Rescue

Evidence for developmental role of 5-HT

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Increased excitability in CA1 pyramidal neurons of knockout mice

5-HT1AR function:
 development vs. adulthood

long term molecular and morphological changes

Mechanism of action of antidepressants

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Hippocampal Atrophy In Recurrent Major Depression

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_{Behavioral tests to detect antidepressant action}

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Parkinson’s Disease: Clinical Characteristics

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Parkinson’s Disease: Environment

MPTP Induced Parkinsonism

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Parkinson’s Disease: Genetics

Parkinson’s Disease and a-Synuclein

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a-Synuclein Biology

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a-Synuclein Function: Vesicles

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What is the nature of a-synuclein dysfunction that leads to dopamine neuron degeneration ?

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a-Synuclein: Gene Targeting Strategy

a-Synuclein:
Knock Out Characterization

MPTP Regimens

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a-Synuclein Null Mice:
Resistance to MPTP-Induced Neurodegeneration

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An Inducible Model of HD

A brief introduction to HD (1):

Striatal specific atrophy of HD

A brief introduction to HD (2):

A brief introduction to HD (3):

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Effect of CAG expansion on htt

Mouse models of HD:

"Davies et al., 1997"

Question:

Inducible mouse model
A model with a switch

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Intranuclear & cytoplasic aggregates

Neuropathology in HD94 mice

HD mice demonstrate a progressive clasping phenotype

Summary

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Protocol

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Summary

Primary striatal cultures from HD94 mice

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Summary (2)

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