Parkinson’s Disease: Genetics
Locus
Inheritance
Onset
Gene
a
-Synuclein
PARK1
Dominant
40’s
PARK2
Recessive
20’s
Parkin
PARK3
Dominant
60’s
??
PARK4
Dominant
30’s
??
PARK5
Dominant
50’s
Ubiquitin C-
terminal
hydrolase L1
PARK6
Recessive
20’s
??
PARK7
Recessive
20’s
??