Beta Adrenergic Signaling in Heart

The Long QT Syndrome:
Dysfunction in Ventricular Repolarization

Decrease in K Channel Activity or Increase in Na Channel Activity Can Prolong ADP (QT Interval)

LQTS:  Genetic Linkage to Multiple Ion Channel Genes

AP Prolongation Can Trigger Arrhythmias

Triggers Are Gene-specific

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b-AR Regulation of Cardiac AP:
A Balance of Inward and Outward Current

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Receptor stimulation to Local Signaling

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Adaptor Proteins:

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Calcium Channel Complex

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Channels as Macromolecular Signaling Complexes

K Channel Complex

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Disruption of Macromolecular Complexes in Disease

AP Prolongation Can Trigger Arrhythmias

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State-dependent Block of Ion Channels by drugs

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Binding Sites of LA’s in Na channels:

Vladimir Yarov-Yarovoy, Jancy C. McPhee, Diane Idsvoog, Caroline Pate, Todd Scheuer, and William A. Catterall

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