Calcium signaling during apoptosis
Growth Factor
Plasma Membrane
Rec
g
Cytoplasm
P
14-3-3
P
2+
ER
Bad
Bad
2
IP3R
Degradation
2+
Akt
+ X ?
Calcineurin
F
2
Bad
CAD
Bcl-x
Digestion
Caspases
TF
M
M
Nucleus
Cytoskeletal Breakdown
Survival
Cell Death
Survival