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Vasoconstrictors
may act through inhibition
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of K+
channels leading to depolarization.
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Endothelin,
vasopressin and angiotensin II
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may act, in part
through inhibition of KATP
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channels via PKC
activity (both direct and
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indirect) through
inhibition of PKA.
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KATP channels
may be activated in several
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pathologic
states:
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(1) Coronary,
cerebral and skeletal muscle
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arteries dilate
in response to hypoxia probably
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through
alteration in ATP levels.
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(2)
Ischemia/reperfusion: Reactive hyperemia
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may cause
increased adenosine
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(3) Acidosis
activates KATP
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(4) Endotoxins
and septic shock can activate
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KATP
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