|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Endothelium-dependent
vasodilators |
|||||||||||||
| Endothelial-derived
nitric oxide relaxes |
|||||||||||||
| VSMC, in part
through effects on K+ |
|||||||||||||
| channels. |
|||||||||||||
| Evidence suggests
that primary |
|||||||||||||
| mechanism is
through KCa, but also via |
|||||||||||||
| KATP
(cross-activation of PKA) |
|||||||||||||
| Endothelium
derived hyperpolarizing |
|||||||||||||
| factor (probably
distinct from |
|||||||||||||
| endothelium
derived relaxing factor/NO) |
|||||||||||||
| may activate KATP. |
|||||||||||||
| Prostacyclin
hyperpolarizes VSMC, |
|||||||||||||
| probably via
activation of KATP. |
|||||||||||||
| Adenosine
activates KATP probably via |
|||||||||||||
| activation of PKA |
|||||||||||||
