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| Elevation of
intravascular pressure |
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| constricts small
arteries (i.e. cerebral) |
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| Cerebral arteries
that lack the b1 subunit |
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| are more
constricted at a given pressure |
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| than controls |
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| Iberiotoxin
(IBTX; blocks BKCa) caused |
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| increase in
constriction in control (note |
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| decrease in
diameter) as compared to KO |
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| Results indicate
that BK channels lacking |
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| the b1 subunit are unable to
contribute |
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| to the regulation
of arterial tone. |
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| Brenner et al Nature 2000;
407:870 |