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Few studies have
addressed the role of uptake or removal of
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intracellular Ca2+.
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Recent studies
have suggested that the [Ca2+]SR may regulate Ca2+
sparks.
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Genetic ablation
of phospholamban leads to chronic elevation in [Ca2+]SR
and
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Ca2+
spark frequency in arterial smooth muscle as compared to controls.
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Elevation of [Ca2+]SR
increased Ca2+ sparks and transient KCa current
frequency,
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but did not
change spark amplitude, spatial spread or decay or the coupling
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ratio.
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Decreasing [Ca2+]SR
reduced spark frequency, amplitude and spatial spread
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causing a
reduction in frequency and amplitude of evoked transient KCa
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currents,
although the coupling ratio was not affected.
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