• PKG phosphorylates RhoA • Phosphorylation may inhibit RhoA by (1) increasing association with guanine nucleotide dissociation inhibitor leading to termination of RhoA activation. (2) ?  reduced interaction with Rho kinase • Decreased RhoA/ROK activity would favor MLCP activity, leading to relaxation. • Telokin-identical to the C-terminus MLCK is PKA/PKG phosphorylated. Phosphorylated telokin may increase MLCP activity, thereby mediating PKG mediated relaxation.