| Hofmann et al J Cell
Science 113: 1671-1676 |
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| PKG
phosphorylates IP3R at two sites in vitro and in vivo |
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| Unclear whether
PKG has a direct effect on Ca2+ release in vivo |
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| IP3R1
co-precipitates with cGKIb and a 125-135 kDa protein termed IRAG |
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| (IP3R-associated cGKI
substrate) |
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| IRAG is located
at ER membrane and is preferentially phosphorylated by CGKIb |
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| which inhibits IP3-induced
Ca2+ release. |
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| Major mechanism
by which NO/cGMP reduces [Ca2+]i and smooth muscle
tone. |
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