|
|
|
| CDI correlates with the affinity of the |
||
| divalent
ion for CaM |
||
|
|
|
| Comparison of cation binding affinities of Calmodulin EF
hands |
||
| EC50
values (mM) |
||
| Ca2+ |
| Sr2+ |
| Ba2+ |
| Effective ionic
radius (Å ) |
| 1.06 |
| 1.21 |
| 1.38 |
|
|
|
| Phosphodiesterase
activity via |
||
| CaM* |
||
| ~2.5 |
| ~25 |
| >1000 |
| Mol Pharmacol 26:75-82, 1984 |
|
|
| *PDE
is one well-studied example of a Ca2+/CaM regulated enzyme, |
|
| allowing
the testing of the ionic dependence of CaM activation; PDE has |
|
| nothing to do
with CDI. |
|