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| High
cholesterol intake leads to reduced cholesterol |
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| synthesis and
increased bile acid synthesis |
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| Both of these
changes represent changes in expression |
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| of rate limiting enzymes |
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| eg. HMG CoA reductase (down) |
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| Cyp7a1 (up) |
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| In addition,
bile acids also regulate gene expression, |
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| in particular of |
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| Cyp7a1 (down) and the |
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| intestinal bile acid binding protein,
I-BABP (up) |
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| Do cholesterol
and/or bile acids act as ligands for |
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| orphan
receptors? |
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