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| Trans-repression---is
it real? |
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| Best evidence for: |
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| GRDim/GRDim
mice have point mutation preventing |
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| dimerization and DNA binding: |
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| Mutant mice
are viable (GR-/GR-
mutants are not!) |
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| No evidence of
transactivation or of active repression |
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| (via nGRE in
promoter of POMC or prolactin genes) |
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