Regulation of Ion Channels by Drugs and Hormones

Adrenergic Regulation of Cardiac Electrical Activity:
 Lessons from Human Disease

LQTS:  Genetic Linkage to Multiple Ion Channel Genes

AP Prolongation Can Trigger Arrhythmias

Triggers Are Gene-specific

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b-AR Regulation of Cardiac AP:
A Balance of Inward and Outward Current

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Receptor stimulation to Local Signaling

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Adaptor Proteins:

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Calcium Channel Complex

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Channels as Macromolecular Signaling Complexes

K Channel Complex

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AP Prolongation Can Trigger Arrhythmias

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State-dependent Block of Ion Channels by drugs

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Use-Dependent Block

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Block Develops During Repetitive electrical Activity

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Targeting Different Channels for Distinct Therapeutic Goals:

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