|
|
| A COOH terminal
motif (RRESAI) on the inwardly rectifying K+ channel |
|
| Kir2.3 binds to
the second PDZ domain of a 95-kD postsynaptic density |
|
| protein called
PSD-95. PKA phosphorylation of the
serine at -2 of the PDZ |
|
| recognition site
uncouples the channel from PSD-95 and results in inhibition |
|
| of K+
conductance. |
|
