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| PKA-serine
threonine kinase composed |
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| of two catalytic
subunits held in an |
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| inactive state by
association with |
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| regulatory dimer. |
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| Binding of two
cAMP molecules to each |
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| regulatory
subunit relieves PKA |
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| autoinhibitory
contact, and allows |
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| phosphorylation
of substrate |
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| Two forms of PKA
holoenzyme exist based |
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| upon type of
regulatory subunit (type I and II) |
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