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| Discrete
localization of type II PKA is due to association of regulatory subunit
with |
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| scaffold protein,
A Kinase Anchoring Protein-AKAP; family now
includes > 50 members |
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| All contain an
amphipathic helix of 14-18 residues that functions to bind to the N-termini
of |
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| the PKA-RII dimer |
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| Each AKAP
contains a unique subcellular targeting domain that restricts its location
within |
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| the cell |
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