|
|
| Determination of
ion channels partners is critical |
|
| for elucidation of
signaling pathways |
|
|
|
|
|
|
|
|
| AKAP’s can also
inhibit phosphatase activity |
||||||
| AKAP220 was found
to bind PP1 and PKA |
||||||
| Determinant for
binding PP1 to AKAP220 |
||||||
| between residues 385-530. However, residues |
||||||
| 1711 and 1901
also affect binding and is a |
||||||
| competitive
inhibitor of PP1. |
||||||
| RII directly
binding to PP1 further inhibits PP1 |
||||||
| activity. |
||||||
