Most homer isoforms contain a coiled coil motif, by which they dimerize and form a complex with two binding sites for homer ligands. The findings that IP3R contained a homer ligand motif led to the discovery that mGluR are physically coupled to their IP3R effector via the homer dimer. Disruption of the homer dimer by the expression of a naturally occurring form of homer (homer 1a, that lacks coiled coil region).
	Thomas J Neurochem 2002 81:407