|
|
|
|
|
| NMDA receptors
are anchored by PSD-95 proteins and PSD-95 is anchored by |
||||
| guanylate-kinase-associated
proteins (GKAPs). Shank proteins
(consist of |
||||
| ankyrin repeats,
SH3 domain, a PDZ domain and long proline-rich domain) |
||||
| provide a
scaffold for several neurotransmitter complexes. The proline rich |
||||
| part, consists of
a homer ligand motif, enabling the binding a homer-mGluR |
||||
| complex. Shank may recruit IP3R into the synapse
as well. |
||||