Intracellular Ca2+
Signaling
Why Calcium?
How cells keep [Ca]i
low
Calcium Concentrations
Ca2+ - a
versatile signal
Ca2+ - a
versatile signal
How Ca2+ is
measured
How cells ↑ [Ca]i
Ca2+ shut-off
pathways
Ca2+
oscillations
Intracellular Ca2+
Targets
Intracellular Ca2+
Targets
EF hand proteins
Calmodulin (CaM)
Classical mode of CaM
regulation
Relief of autoinhibition
CaMKII
New modes of CaM
interaction
New modes of CaM
interaction
New modes of CaM regulation
Intracellular Ca2+
Targets
C2 Domains
C2 domains - PKC
Synaptotagmin and
neurotransmitter release