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| Evidence-based guidelines - |
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| Types of evidence |
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| Efficacy - Does the agent “work” under |
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| ideal,
“laboratory” conditions? |
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| Often studied
with the randomized clinical |
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| trial |
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| n | conducted in
highly controlled settings |
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| n | often expensive |
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| n | may present
ethical constraints |
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| n | may not reflect
the outcomes obtained when used in |
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| a typical
practice setting |
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| 14 |