21
Product Safety
•Following
application of varnish on four children, ages 4, 5, 12 and 14: “Peak plasma
fluoride concentrations of 3.2 to 6.3 micromolar were found within two hours of
treatment… These levels were comparable with those found after brushing with
a fluoridated toothpaste (3.63 +/- 0.45 mmol/h) or
after ingesting a 1-mg F tablet (4.47 +/- 0.47 mmol/h) and were considerably
lower than those reported for APF gels (16 to 76 mmol/h)
If 0.50 ml of varnish is
consumed this is 11.3 mg F and is
1/9 the potential toxic dose for a 44lb (20kg) child. Clark et.al.
1/9 the potential toxic dose for a 44lb (20kg) child. Clark et.al.
