Pharmacogenetics Is….
n The influence of genetic traits on the magnitude or
type of toxic effects of drugs.
n The influence of genetic traits on the magnitude or
type of therapeutic effects of drugs.
n A genetic determinant of overall drug response;  not
a measurement of physiological status!
n PGenetics:  Targeted study of gene variants
determining drug response
n PGenomics: Genome wide study of genetic
determinants, including the study of gene expression
(requiring RNA as a study material)